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RIS Approves $150,000 in Research Grants for UMN

Rein in Sarcoma proudly announces a $150,000 research grant approved by the Rein in Sarcoma Board in January, 2019. This grant will fund the following three exciting University of Minnesota Masonic Cancer Center projects:

Masato Yamamoto, MD, PhD

MYOG Promoter-Controlled Oncolytic Adenovirus to Treat PAX3-FOXO1-Positive Rhabdomyosarcoma
Masato Yamamoto, MD, PhD – Principle Investigator, H Yoshida, MD, PhD – Co-Investigator | $50,000

Rhabdomyosarcoma (RMS) is a malignant skeletal muscle tumor which occurs in children and adolescents. About 30% of RMSs are alveolar type (ARMS), and most of ARMS patients has PAX3-FOXO1 fusion gene created by chromosomal translocation. PAX3-FOXO1 is a trans-activator, which increases expression of many cancer-related genes, causing unfavorable outcomes such as higher prevalence of metastases. PAX3-FOXO1-positive ARMS therefore has worst prognosis among RMSs and needs novel therapies desperately.
We have been developing oncolytic adenoviruses (OAds) which selectively replicate in and kill the cancer cells. We have reported tumor-specific promoter-controlled OAds are effective when the promoter activity has a large difference between tumor and normal tissue. We therefore searched a promoter with such profile for RMS.
Myogenin (MYOG) play important roles for the skeletal muscle differentiation process. In ARMS, PAX3-FOXO1 dictates MYOG expression and contributes to tumor development. Interestingly, MYOG promoter (MYOGp) with mutation in MEF2 site shows strongly activity in PAX3-FOXO1-positive ARMS but no activity in normal muscles. We therefore will develop OAd regulated by the mutant MYOG promoter in order to target ARMS using PAX3-FOXO1 as a trigger. Our preliminary data has already shown that the OAd controlled by MYOGp with MEF2 mutation specifically kills PAX3-FOXO1positive cells. However, clinical translation requires further assessment of the function of our OAd with mutant MYOG promoter.
In this project, we will first assess OAd function in vitro and then analyze tumor suppression, intratumoral virus spread, and adverse effect in vivo. We believe this novel therapy can change the treatment of PAX3-FOXO1-positive ARMS.

David-Largaespada-PhD

SHH signaling genetic alterations: A relevant and targetable trait in peripheral nerve sheath sarcomas
David Largaespada, PhD | $50,000

Neurofibromatosis type 1 syndrome (NF1) is a common genetic disease. NF1 patients are predisposed to several kinds of sarcoma, especially malignant peripheral nerve sheath tumors (MPNSTs) which occur in adolescence or young adulthood in NF1 patients. Half of all MPNSTs occur in NF1 patients, the other half occur in non-NF1 patients. MPNSTs, about 10% of all soft tissue sarcoma, are among the most aggressive. These are hard tumors to treat and the overall 5-year survival rate is about 50%. Surgery and radiation seem to be effective, but chemotherapy may or may not be effective. New treatments are needed. We’ve recently learned, through our research, that a gene called PTCH1 is inactivated, in some MPNSTs. This subset of MPNSTs is likely to be sensitive to an FDA approved drug called Vismodegib (trade name Erivedge) which is used to treat basal cell carcinomas of the skin, which also usually have mutations in PTCH1. We must do some lab research on MPNST samples growing in tissue culture dishes and in mice, to make sure this is going to be true. We can then try Erivedge in patients with PTCH1 mutant MPNST. This work could finally provide a new form of therapy for some MPNST patients. We have an FDA approved drug ready to go and this idea could be rapidly tried in people.

Logan-Spector, PhD

Registry-based analysis of risk and survival for young-onset sarcomas
Logan Spector, PhD | $50,000

Sarcomas are an understudied group of over 50 connective tissue cancers that are rare, deadly, and disproportionately occur early in life. Because sarcomas are so rare, little is known about the factors driving development and progression in young onset cases (<40 years). However, emerging evidence suggests that pediatric sarcomas may originate prenatally or in early life. It’s currently unknown whether these associations extend to young-adult cases. Once a sarcoma develops, patient’s whose disease progresses to metastasis prior to diagnosis experience much worse outcomes compared to those whose tumors remain localized, yet whether a delayed diagnosis contributes to distant spread is unknown. Beyond staging, prognosis is based on grading systems that are designed to be applied universally to all sarcomas without regard to subtype specific differences in behavior. It is clear that more precise analyses of factors related to sarcoma development and progression by subtype and specific body site of occurrence are needed, particularly because sarcoma patients report being frustrated by the inability to find information regarding their specific subtype of sarcoma. Yet such analyses require larger sample sizes than attained to date. We aim to overcome this limitation by assembling the largest population-based case-control study and largest clinical cohort of young-onset sarcomas by linking the population-based cancer and birth registries of 7 of the 11 largest states. With this unique dataset, we propose 3 specific aims that will serve to address a number of gaps in knowledge about young onset sarcoma etiology and outcomes.

Join the Fun – 2019 Party in the Park Kickoff

2019 PIP Kickoff graphic

Join us at the 2019 Party in the Park Kickoff meeting and celebration, Monday, March 18.  It's a fun event that will jump start your involvement in the planning of Rein in Sarcoma's signature event. Meet at Surly Brewing Company - we're hoping to start with a brewery tour, enjoy some snacks and beverages, and begin planning for a great Party in the Park!

Location:
Surly Brewing Company
520 Malcolm Ave SE
Minneapolis, MN, 55414

Map and directions

Kickoff Schedule:
5:45 pm Brewery Tour (optional)
6:30 pm Social Time and Registration
7:00-8:30 pm Kickoff Meeting and Celebration

Highlights:

  • Welcome and Introductions - meet the 2019 Co-Chairs: Amy Hoban and Allison Mulcahy
  • Celebrate Rein in Sarcoma's Impact
  • 19th Anniversary Multi-media Presentation
  • New 2019 Highlights
  • Share Your Ideas and Get Involved
  • Initial Sub-committee Meetings including: Party Program, Silent Auction, Sarcoma Family Picnic, Logistics

This is the perfect opportunity to meet other volunteers, share ideas, and get involved! Please RSVP by March 15 so we can plan accordingly. However, please join us whether or not you RSVP! Bookmark the 2019 Party in the Park page - we will continue to update as plans come into place.

Questions: Call (763) 205-1467

Featured Volunteer Needs – January 2019

RIS Volunteers
RIS depends on volunteers to make our mission a reality. Current volunteer opportunities include:

Patient and Family Support Committee

Rein in Sarcoma is looking for compassionate volunteers to help us serve the needs of sarcoma patients and their loved ones. Our Patient and Family Support Committee reaches out to sarcoma patients and their loved ones by providing peer-to-peer mentoring, organizing social gatherings for those affected by sarcoma, providing totes of hope bags for newly diagnosed and relapsed sarcoma patients, and by providing informational notebooks to newly diagnosed sarcoma patients. This committee has monthly meetings and plans and attends several gatherings throughout the year. Next meeting is Tuesday, January 8.

For more information about this volunteer position contact Connie Dow at Ph: 844-727-2662 ext 1 or by email.

Apply for this position at: New Volunteer Form

Red Flags Committee

The Rein in Sarcoma Red Flags Committee Rein in Sarcoma Red Flags committee is looking for additional committee members to work on a variety of education programs for healthcare professionals and the public. Program needs include writing, editing and presenting. Depending on the project, time commitment will vary. Our next committee meeting will be scheduled for February 7. If interested, please contact Sue Wyckoff or Naomi Bowman.

For more information about this volunteer position contact Connie Dow at Ph: 844-727-2662 ext 1 or by email.

Apply for this position at: New Volunteer Form

For more information about these volunteer positions contact Connie Dow at Ph: 844-727-2662 ext 1 or by email.

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